AREDIA (Pamidronate disodium)
Warning: Aredia and other bisphosphonates have been associated with renal
toxicity. This was manifested as deterioration of renal function
and possible renal failure. Single doses of this medication should
not exceed 90 mg because of the risk of clinically significant deterioration in renal function that could lead
to renal failure. This medication may cause fetal harm when given
to pregnant women. Women of childbearing potential should be
advised to avoid becoming pregnant.
Indications: Aredia, pamidronate disodium (APD), is
a bone-resorption inhibitor. It is administered intravenously and
comes in vials of 30-mg or 90-mg. It is used to treat high blood
calcium and certain bone problems associated with some types of cancer. It can also be used to treat Paget’s disease that causes weak and abnormal
conjunction with adequate hydration it is indicated for the treatment of moderate to severe hypercalcemia
associated with malignancy. This can be with or without bone
metastases. Patients who have non-epidermoid or epidermoid tumors
have responded to treatment with this medication. An integral part
of hypercalcemia therapy is its use of vigorous saline hydration.
Throughout the treatment patients should be hydrated adequately, but caution should be taken not to over
hydrate. Over hydration could be an issue for patients who have
regards to Paget’s disease, this drug has been effective in reducing biochemical markers in the patients with
this disease. It is used when Paget’s disease has failed to or no
longer responds to other treatments.
Severity as well as symptoms of
hypercalcemia should be given consideration. If treating mild,
asymptomatic hypercalcemia a vigorous saline hydration may be sufficient. Special consideration should be given to patients with cardiac failure to
not over hydrate.
recommended use for moderate hypercalcemia is 60 to 90 mg given in a single dose intravenously infused over 2 to
24 hours. If a patient has preexisting renal insufficiency, a
longer infusion may reduce the risk for renal toxicity.
severe hypercalcemia it is recommended that 90 mg of this drug is given in a single dose through intravenous
infusion over 2 to 24 hours. If there is preexisting renal
insufficiency a longer infusion may reduce the risk for renal toxicity.
nonexistent,overdose of aredia can occur. If that happens, contact your doctor or emergency room immediately;
they will make an intravenous infusion of calcium in your body to eliminate or reduce symptoms. Symptoms of
Aredia overdose include:
change in taste.
you missed a dose of Aredia, talk to your doctor to know what you should do. Your doctor may advise you to take
or completely skip the missed dose. Taking chemotherapy drugs is a serious health concern; contact your doctor
before the date schedule for the therapy if you cannot go to the hospital for the treatment. Do not stay home
because you are experiencing side effects; Aredia cause side effects in most patients.
Bisphosphonates have been associated with renal toxicity manifested as deterioration of renal function and
potential renal failure. The risk of tese complications increases when the drug with certain agents.
Aredia is contraindicated in cases of allergy to one of its constituents. Tell your doctor or pharmacist about any
history of allergy to:
is contraindicated in pregnancy or breastfeeding. See your doctor immediately if you become pregnant during the
treatment; Aredia can cause serious problems to the fetus.
taking Aredia, tell your doctor if you have or had a history of thyroid surgery, seizures, liver or kidney
disease, thyroid surgery or dental surgery.
These factors may obligate him to prescribe another drug or change the way you should use the drug.
Some products that may interact with Aredia are other bisphosphonates, such as alendronate; and other medications
that affect the kidneys such as ibuprofen or naproxen. Make sure your
doctor and pharmacist have a complete list of all the medication you are taking both by prescription and over the
effects: Aredia may
cause side effects which can be mild or severe, temporary or permanent. Most common Aredia side effects
diarhea; nausea and
difficulty sleeping; abdominal
or stomach pain; bone
indigestion; loss of appetite; swelling
of your hands, arms, feet, ankles, or lower legs; difficulty
or painful urination; fatigue or general weakness; and Pain,
redness, or swelling at the injection site.
rare, Aredia can cause serious side effects which require immediate medical attention; contact your doctor
immediately if you experience any of these symptoms:
pain or tearing
numbness and pain
or swollen gums
of the teeth
or black and tarry stools
tightening of muscles
or tingling around your mouth or cheeks.
1 - santecheznous.com, Aredia
2 - nlm.nih.gov
For more chemotherapy side effects and steps to take manage them, please visit www.cancereffects.com